Browsing by Author "Ocaranza, María Paz"

Now showing items 1-20 of 33

    • Angiotensin I-converting enzyme gene polymorphism influences chronic hypertensive response in the rat ... 
      Ocaranza, María Paz; Piddo Mijares, Ana María; Faúndez Fuentes, Perla Andrea; Lavandero González, Sergio; Jalil Milad, Jorge (LIPPINCOTT WILLIAMS & WILKINS, 2002-03)
      Background and objective In humans, the insertion/ deletion polymorphism in the anglotensin (Ang) I converting enzyme (ACE) gene significantly determines ACE activity. The deletion allele induces higher ACE levels and is ...
    • Angiotensin I-converting enzyme insertion/delection polymorphism and adrenergic response to exercise in ... 
      Jalil Milad, Jorge; Córdova, Samuel; Ocaranza, María Paz; Schumacher, Erwin; Braun J., Sandra; Chamorro, Gastón; Fardella, Carlos E.; Lavandero González, Sergio (International Medical Science for Experimental and Clinical Research, 2002)
      The insertion/delection ACE polymorphism (ACE I/D) regulates different levels of circulating and tissue ACE activities, which may induce diverse adrenergic responses to physiological stimuli. The aim of this study was ...
    • Angiotensin I-converting enzyme modulates neutral endopeptidase activity in the rat 
      Oliveri Pérez, Carla Giovanna; Ocaranza, María Paz; Campos Bastidas, Ximena; Lavandero González, Sergio; Jalil Milad, Jorge (LIPPINCOTT WILLIAMS & WILKINS, 2001-09)
      Angiotensin I is a substrate for both ACE and for neutral endopeptidase 24.11 (NEP). We hypothesized that high ACE expression is related to low NEP activity. Accordingly, circulating and tissue NEP and ACE activities were ...
    • Antihipertensivos en pacientes con COVID-19 
      Ramírez-Sagredo, Andrea; Ramírez-Reyes, Andrés; Ocaranza, María Paz; Chiong, Mario; Riquelme, Jaime A; Jalil, Jorge E.; Lavandero, Sergio (SciELO Agencia Nacional de Investigacion y Desarrollo (ANID), 2020)
    • Circulating vascular cell adhesion molecule-1 (sVCAM-1) is associated with left atrial remodeling in ... 
      Contreras Briceño, Felipe Andrés; Herrera, Sebastián; Vega Adauy, Julián; Salinas, Manuel; Ocaranza, María Paz; Jalil, Jorge E.; Mandiola, Jorge; Garcia Nannig, Lorena del Pilar; Chiong Lay, Mario Martin; Castro, Pablo F.; Lavandero González, Sergio Alejandro; Gabrielli, Luigi (Frontiers Media, 2021)
      An increased risk of atrial fibrillation (AF) has been demonstrated in high-performance athletes. Soluble vascular adhesion molecule-1 (sVCAM-1), a biomarker involved in inflammation and cardiac remodeling, is associated ...
    • Early expression of monocyte chemoattractant protein-1 correlates with the onset of isoproterenol-induced ... 
      Copaja Soto, Miguel; Valenzuela, Rodrigo; Saldaña, Adiela; Ocaranza, María Paz; Jalil Milad, Jorge; Vio, Carlos; Lijnen, Paul; Ordenes, Gamaliel; Vivar Sánchez, Raúl; Lavandero González, Sergio; Díaz Araya, Guillermo (SAGE PUBLICATIONS LTD, 2008-09)
      Introduction. Isoproterenol treatment of Brown Norway Lewis rats (high and low plasma angiotersin-I-converting enzyme activity., respectively) results in similar cardiac hypertrophy but higher cardiac fibrosis in Brown ...
    • Early prevention of experimental left ventricular hypertrophy in experimental hypertension and angiotensin ... 
      Gálvez, Anita; Ocaranza, María Paz; Lavandero González, Sergio; Jalil Milad, Jorge (EDICIONES DOYMA S/L, 2001-11)
      Introduction. Angiotensin II levels can be partially inhibited during chronic administration of angiotensin converting enzyme (ACE) inhibitors, limiting from a clinical point of view its efficacy in the treatment of ...
    • Effect of hypertension on angiotensin-(1-7) levels in rats with different angiotensin-I converting enzyme ... 
      Ocaranza, María Paz; Palomera, Cristián; Román, Maritza; Bargetto, Jorge; Lavandero González, Sergio; Jalil Milad, Jorge (PERGAMON-ELSEVIER SCIENCE LTD, 2006-02-28)
      To determine circulating angiotensin-(1-7) [Ang-(1,7)] levels in rats with different angiotensin converting enzyme (ACE) genotypes and to evaluate the effect of hypertension on levels of this heptapeptide, plasma levels ...
    • Enalapril attenuates downregulation of angiotensin-converting enzyme 2 in the late phase of ventricular ... 
      Ocaranza, María Paz; Godoy, Iván; Jalil Milad, Jorge; Varas, Manuel; Collantes, Patricia; Pinto, Melissa; Román, Maritza; Ramírez, Cristián; Copaja, Miguel; Díaz Araya, Guillermo; Castro, Pablo; Lavandero González, Sergio (LIPPINCOTT WILLIAMS & WILKINS, 2006-10)
      The early and long-term effects of coronary artery ligation on the plasma and left ventricular angiotensin-converting enzyme (ACE and ACE2) activities, ACE and ACE2 mRNA levels, circulating angiotensin (Ang) levels [Ang ...
    • IGF-1 regulates apoptosis of cardiac myocyte induced by osmotic-stress 
      Morales, María Paz; Gálvez, Anita; Eltit Ortega, José Miguel; Ocaranza, María Paz; Díaz Araya, Guillermo; Lavandero González, Sergio (ACADEMIC PRESS INC, 2000-04-21)
      Insulin-like growth factor-1 (IGF-1) is a natural protectant of cardiac myocytes that has been shown to improve cardiac function. The role of IGF-1 in attenuating apoptosis induced by osmotic stress (sorbitol, SOR) or by ...
    • Increased active phase atrial contraction is related to marathon runner performance 
      Gabrielli, Luigi; Herrera, Sebastián; Contreras Briceño, Felipe; Vega, Julián; Ocaranza, María Paz; Yáñez, Fernando; Fernández, Rodrigo; Saavedra, Rodrigo; Sitges, Marta; García Nannig, Lorena; Chiong Lay, Mario; Lavandero González, Sergio; Castro, Pablo F. (Springer Verlag, 2018)
      © 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Left atrial (LA) contraction is essential for left ventricular (LV) filling during exertion. We sought to evaluate the relationship of LA contraction ...
    • Increased aortic NADPH oxidase activity in rats with genetically high angiotensin-converting enzyme levels 
      Jalil Milad, Jorge; Pérez, Alfonso; Ocaranza, María Paz; Bargetto, Jorge; Galaz, Alfonso; Lavandero González, Sergio (LIPPINCOTT WILLIAMS & WILKINS, 2005-12)
      In humans and rats, angiotensin I-converting enzyme activity is significantly determined by a gene polymorphism. Homozygous Brown Norway rats have higher plasma angiotensin I-converting enzyme activity and circulating ...
    • Interacción entre los polimorfismos del receptor ß1 y ß2 adrenérgico como predictor de riesgo de insuficiencia ... 
      Moraga, Francisco; Troncoso, Rodrigo; Mellado, Rose Marie; Díaz Araya, Guillermo; Vukasovic Ramírez, José Luis; Greig, Douglas; Pérez, Osvaldo; García Nannig, Lorena; Roldán, Juan; Ocaranza, María Paz; Jalil Milad, Jorge; Chiong Lay, Mario; Castro, Pablo (SOC MEDICA SANTIAGO, 2008-11)
      Background: beta adrenergic receptors (AR) are highly polymorphic and important regulators of cardiovascular homeostatis. Among these, beta(1) and beta(2) AR regulate cardiac contractility and frequency and are important ...
    • Isoproterenol and angiotensin I-converting enzyme in lung, left ventricle, and plasma during myocardial ... 
      Ocaranza, María Paz; Díaz Araya, Guillermo; Chiong Lay, Mario; Muñoz, David; Riveros, Juan Pablo; Ebensperger González, Roberto; Sabat, Sebastián; Irarrázabal, Pablo; Jalil Milad, Jorge; Lavandero González, Sergio (LIPPINCOTT WILLIAMS & WILKINS, 2002-08)
      This study investigated whether long-term administration of isoproterenol (ISO) induces differential expression of angiotensin-converting enzyme (ACE) in lung, plasma, and left ventricle (LV) during development of left ...
    • Levels of plasma angiotensin-(1-7) in patients with hypertension who have the angiotensin-1-converting ... 
      Jalil Milad, Jorge; Palomera Gómez, Cristián Alejandro; Ocaranza, María Paz; Godoy, Iván; Román, Maritza; Chiong Lay, Mario; Lavandero González, Sergio (EXCERPTA MEDICA INC, 2003-09-15)
      In patients with hypertension who have the DD-ACE genotype (higher angiotensin-converting enzyme [ACE] activity), plasma levels of angiotensin-(1-7) are 4 times lower than in patients with the II-ACE genotype (lower ACE ...
    • Markedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure 
      Ocaranza, María Paz; Gabrielli, Luigi; Mora, Italo; García Nannig, Lorena; McNab, Paul; Godoy, Iván; Braun, Sandra; Córdova, Samuel; Castro, Pablo; Novoa, Ulises; Chiong Lay, Mario; Lavandero González, Sergio; Jalil, E. (MOSBY-ELSEVIER, 2011-05)
      Background The small guanosine triphosphatase Rho and its target Rho-kinase have significant roles in experimental remodeling and ventricular dysfunction, but no data are available on Rho-kinase activation in patients with ...
    • Neutral endopeptidase and angiotensin I converting enzyme insertion/deletion gene polymorphism in humans 
      Jalil Milad, Jorge; Ocaranza, María Paz; Oliveri, C.; Córdova, S.; Godoy, I.; Chamorro, G.; Braun, S.; Fardella, Carlos E.; Michel, J. B.; Lavandero González, Sergio (NATURE PUBLISHING GROUP, 2004-02)
      Neutral endopeptidase (NEP) hydrolyses angiotensins (Ang) I and II and generates angiotensin-(1-7) [Ang-(17)]. In humans, the insertion/deletion (I/D) angiotensin- I converting enzyme ( ACE) gene polymorphism determined ...
    • Niveles de angiotensina (1-7) en ratas con distinto genotipo de enzima convertidora de angiotensina I y ... 
      Palomera Gómez, Cristián Alejandro; Ocaranza, María Paz; Román, Maritza; Chiong Lay, Mario; Lavandero González, Sergio; Jalil Milad, Jorge (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2003)
      La mayor actividad de la enzima convertidora de angiotensina I (ECA) determina mayores niveles de angiotensina (Ang) II y menores de Ang-(1-7). Hemos observado mayores niveles de Ang II en ratas normotensas con mayor ...
    • Novel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) 
      Westermeier, Francisco; Bustamante, Mario; Pavez, Mario; García Nannig, Lorena; Chiong Lay, Mario; Ocaranza, María Paz; Lavandero González, Sergio (Elsevier, 2015)
      Insulin-like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) have been proposed to be important mediators in cardioprotection. A large body of evidence indicates that insulin like growth factor-1 has pleotropic ...
    • Osmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes 
      Navarro, Paola; Chiong Lay, Mario; Volkwein, Karen; Moraga, Francisco; Ocaranza, María Paz; Jalil Milad, Jorge; Sun, Woo Lim; Jeong-Ah, Kim; H., Moo Kwon; Lavandero González, Sergio (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008-07-25)
      Changes in cardiac osmolarity occur in myocardial infarction. Osmoregulatory mechanisms may, therefore, play a crucial role in cardiomyocyte survival. Tonicity-responsive enhancer binding protein (TonEBP) is a key ...